a tool for identifying drug-targetable redox-active disulphides

Ig lambda-2 chain C region

Intramolecular

Cysteine 27 and cysteine 85

A redox-regulated disulphide may form within Ig lambda-2 chain C region between cysteines 27 and 85 (135 and 193 respectively in this structure).

Details

Redox score ?

77

PDB code

Structure name

crystal structure of the 13f6-1-2 fab fragment bound to its ebola virus glycoprotein peptide epitope

Structure deposition date

2007-07-02

Thiol separation (Å)

2

Half-sphere exposure sum ?

89

Minimum pK_a ?

nan

% buried

nan

Peptide accession

Residue number A

27

Residue number B

85

Peptide name

Ig lambda-2 chain C region

Ligandability

Cysteine 27 of Ig lambda-2 chain C region

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 85 of Ig lambda-2 chain C region

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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